KMID : 1197720160090020097
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´ëÇÑÆÄŲ½¼º´ ¹× ÀÌ»ó¿îµ¿Áúȯ ÇÐȸÁö 2016 Volume.9 No. 2 p.97 ~ p.103
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Cardiovascular Autonomic Dysfunction in Mild and Advanced Parkinson¡¯s Disease
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Kim Joong-Seok
Lee Si-Hoon Oh Yoon-Sang Park Jeong-Wook An Jae-Young Park Sung-Kyung Han Si-Ryung Lee Kwang-Soo
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Abstract
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Objective: The purpose of the present study was to investigate cardiovascular autonomic dysfunction in patients with Parkinson¡¯s disease (PD) with mild to severe stages of motor symptoms and to compare cardiovascular autonomic dysfunction between drug-naive and dopaminergic drug-treated groups.
Methods: This study included 188 PD patients and 25 age-matched healthy controls who underwent head-up tilt-testing, 24-h ambulatory blood pressure (BP) monitoring and 24-h Holter monitoring. Autonomic function test results were evaluated among groups categorized by motor symptom severities (mild vs. moderate vs. severe) and treatment (drug-naive or dopaminergic drug treatment).
Results: Orthostatic hypotension and supine hypertension were more frequent in patients with PD than in healthy controls. The frequencies of orthostatic hypotension, supine hypertension, nocturnal hypertension and non-dipping were not different among groups. Additionally, no significant differences were detected in supine BP, orthostatic BP change, nighttime BP, nocturnal BP dipping, or heart rate variabilities among groups.
Conclusions: Cardiovascular autonomic dysfunction is not confined to moderate to severe PD patients, and starts early in the course of the disease in a high proportion of PD patients. In addition, dopaminergic drug treatments do not affect cardiovascular autonomic function.
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KEYWORD
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Parkinson¡¯s disease, Autonomic dysfunction, Cardiovascular, Symptom severity, Dopaminergic treatment
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